Detailed Project Report on ONCOLOGY MANUFACTURING (Tablet (Letrozole), Temozolomide Capsules, Oncology Tablets, Oncology Capsules, Oncology Injections)

ONCOLOGY MANUFACTURING

(Tablet (Letrozole), Temozolomide Capsules,

Oncology Tablets, Oncology Capsules, Oncology Injections)

[CODE NO.4207] 

The development of Indian Drugs and pharmaceuticals Industry was not commensurate with the size of this country and the growing needs of people, when Indian embarked on its planned economic expansion industry has been substantial and many sides with the result that it has becomes one of the leading industries. India is now producing a larger quantity of varied pharmaceuticals products. 

Oncology is a branch of study and treatment of cancer. Cancer is disease in which abnormal cells grow and divide without control. Oncology drugs help in diagnosis cancer. Some of the causes of cancer are tobacco and smoking, viral infections, genetic causes, carcinogens, bacterial infections, physical activities, eating habits and age.

Various types of cancer that can be treated by oncology drugs are blood cancer, endocrine cancer, lung cancer, bone cancer, skin cancer, genitourinary cancer, gastrointestinal cancer, breast cancer, eye cancer, head and neck cancers and gynaecologic cancer. On the basis of treatment, oncology drugs market can be segmented into chemotherapy, immunotherapy, surgery, radiation therapy, stem cell transplant, hormone therapy and others.

North America, followed by Europe, has the largest market for oncology drugs due to new drug development, government initiatives and developed healthcare infrastructure in this region. Asia is expected to show high growth rate in the oncology drugs market in next few years due to increasing incidence of cancer cases, rise in the use of tobacco products and growth in aging population in the region.

Technological advancement, increasing incidence of various type of cancers, rise in need for R&D activities in cancer and growing concerns over high death rates due to cancer are driving the market for oncology drugs. In addition, introduction of new drugs and therapies for cancer and government support to improve healthcare condition are expected to drive the market for oncology drugs.

However, high cost of cancer treatments, strict government regulations, huge investment involvement in the development and clinical trials of the therapies and side effects of cancer treatments are some of the major factors restraining the growth for global oncology drugs market.

Growing demographics and economies in the developing countries such as China and India are expected to offer good opportunities in oncology drugs market in Asia.

In addition, new innovations in cancer drugs and therapies and rise in awareness about the new drugs and therapies available in the market are expected to offer new opportunities for global oncology drugs market. Personalized medicines, increasing number of mergers and acquisitions, new product launches and rise in number of collaborations and partnerships are some of the trends that have been observed in global oncology drugs market.

COST ESTIMATION

Plant Capacity                                    270000 Nos/Day  

Land & Building (6000 sq.mt.)  Rs. 4.83 Cr    

Plant & Machinery                              Rs. 5.85 Cr 

Working Capital for 2 Months    Rs.23.16  Cr 

Total Capital Investment                  Rs. 34.55 Cr 

Rate of Return                                    47%

Break Even Point                               32%

• INTRODUCTION
• ONCOLOGY AND CRITICAL CARE
• ONCOLOGY AND ITS TREATMENT
• CHEMOTHERAPY
• SOLID TUMORS
• FOR LUNG CANCER
• FOR ORAL CANCER
• FOR COLORECTAL CANCER
• FOR PROSTATE
• FOR MRCC (MET. RENAL CELL CARCINOMA)
• IN WOMEN, THE MOST PREVALENT CANCERS ARE CERVIX, BREAST 
•    AND OVARY.
• FOR CERVIX CANCERS
• FOR BREAST CANCER
• IN OVARIAN CANCER
• HAEMATOLOGICAL MALIGNANCIES
• SUPPORTIVE THERAPY
• CRITICALLY ILL PATIENTS
• ANTICOAGULANTS
• MARKPARIN- ENOXAPARIN (40, 60 MG)
• PROPERTIES & CHARACTERISTICS OF INJECTION (DISTILLED WATER)
• CHARACTERISTICS OF INJECTABLES:-
• USES AND APPLICATIONS
• ADVANTAGES OF PARENTERAL PRODUCTS (INJECTABLES):-
• OXYTOCIN INJECTION (PITUITARY):-
• B.I.S. SPECIFICATION
• RAW MATERIALS FOR INJECTION DISTILLED WATER
• (DISTILLED WATER AMPOULES)
• WATER PROPERTIES
• KMNO4 (POTASIUM PERMANGANATE):-
• GLASS AMPOULES
• INJECTION WATER
• SALINE (NORMAL SALINE SOLUTION FOR INJECTION)
• ACIDITY OR ALKALINITY:-
• BARIUM:-
• CALCIUM AND MAGNESIUM:-
• HEAVY METALS:-
• MARKET OVERVIEW OF ONCOLOGY DRUGS
• THE ONCOLOGY DRUGS MARKET IS SEGMENTED BY TYPE INTO
• THE ONCOLOGY DRUGS MARKET IS SEGMENTED BY DRUG CLASS 
•     TYPE INTO
• THE ONCOLOGY DRUGS MARKET IS SEGMENTED BY DISTRIBUTION 
•    CHANNEL INTO
• THE ONCOLOGY DRUGS MARKET IS SEGMENTED BY ROUTE OF ADMINISTRATION INTO
• THE ONCOLOGY DRUGS MARKET IS SEGMENTED BY DRUG 
•     CLASSIFICATION INTO
• PRIME COMPETITORS IN THIS ONCOLOGY DRUGS MARKET ARE 
•     AS FOLLOWS:
• SOME OTHER PROMINENT COMPETITORS ARE AS FOLLOWS:
• FUTURE OF ONCOLOGY DRUGS
• ONCOLOGY DRUG MARKET IN INDIA
• FINDINGS FROM A STUDY CONCLUDED THE CANCER SCENARIO 
•     IN INDIA THAT:
• MARKET SIZE
• S.W.O.T. ANALYSIS
• STRENGTHS
• WEAKNESS
• OPPORTUNITIES
• INDUSTRY CHALLENGES
• LATEST DEVELOPMENTS IN INDIAN ONCOLOGY DEPARTMENT
• CIPLA:
• ZYDUS CADILA:
• BIOCON LTD.:
• NEW PLAYERS IN THE INDIAN ONCOLOGY MARKET
• AUROBINDO PHARMA LTD.:
• ALEMBIC PHARMA LTD.:
• GLOBAL ONCOLOGY MARKET AND PROCESS SOLUTION
• ONCOLOGY AND ITS TREATMENT
• CHEMOTHERAPY
• GENERIC DRUGS IN ONCOLOGY
• MANUFACTURING PROCESS OF INJECTION WATER
• FILLING OF AMPOULES
• PROCESS FLOW CHART
• PROCESSING OF PARENTRAL PRODUCTS INJECTIONS
• 1. ENVIRONMENTAL CONTROL:-
• TECHNIQUES INVOLVED IN THE PREPARATION OF INJECTABLES
• PACKING OF PARENTERAL PRODUCTS (PACKING OF INJECTABLES)
• PROCESSING OF CONTAINES & CLOSURES:-
• EVALUATION OF PARENTERAL PRODUCTS
• A. STERILITY TEST:-
• PYROGEN TEST:-
• CLARITY TESTS:-
• LEAKAGE TESTS:-
• FLOW DIAGRAM FOR PREPARATION OF INJECTABLES
• MANUFACTURING PROCESS OF INJECTIONS
• MANUFACTURING PROCESS OF TABLETS
• FLOW DIAGRAM OF TABLET MAKING PLANT
• CAPSULE FILLING AND SEALING
• (A) DILUENTS:
• (B) PROTECTIVE SORBENTS:
• (C) GLIDANTS:
• (D) ANTI-DUSTING COMPOUNDS:
• FILLING:
• SEALING AND LOCKING:
• FLOW DIAGRAM OF CAPSULE MAKING PLANT
• ONCOLOGY DRUGS
• FORMULATION OF LETROZOLE TABLETS
• FORMULATION OF ENZALUTAMIDE CAPSULES
• FORMULATION OF TEMOZOLOMIDE CAPSULE
• ADVANCED COLORECTAL CANCER
• ADJUVANT TREATMENT OF COLORECTAL CANCER
• ADVERSE EFFECTS
• DOSAGE AND ADMINISTRATION
• DOSAGE
• PRINCIPLES OF PLANT LAYOUT
• MAJOR PROVISIONS IN ROAD PLANNING FOR MULTIPURPOSE SERVICE ARE:
• PLANT LOCATION FACTORS
• PRIMARY FACTORS
• 1. RAW-MATERIAL SUPPLY:
• 2. MARKETS:
• 3. POWER AND FUEL SUPPLY:
• 4. WATER SUPPLY:
• 5. CLIMATE:
• 6. TRANSPORTATION:
• 7. WASTE DISPOSAL:
• 8. LABOR:
• 9. REGULATORY LAWS:
• 10. TAXES:
• 11. SITE CHARACTERISTICS:
• 12. COMMUNITY FACTORS:
• 13. VULNERABILITY TO WARTIME ATTACK:
• 14. FLOOD AND FIRE CONTROL:
• EXPLANATION OF TERMS USED IN THE PROJECT REPORT
• 1. DEPRECIATION:
• 2. FIXED ASSETS:
• 3. WORKING CAPITAL:
• 4. BREAK-EVEN POINT:
• 5. OTHER FIXED EXPENSES:
• 6. MARGIN MONEY:
• 7. TOTAL LOAD:
• 8. LAND AREA/MAN POWER RATIO:
• PROJECT IMPLEMENTATION SCHEDULES
• INTRODUCTION
• PROJECT HANDLING
• PROJECT SCHEDULING
• PROJECT CONSTRUCTION SCHEDULE
• TIME SCHEDULE
• SUPPLIERS OF PHARMACEUTICAL PLANTS AND MACHINERY
• SUPPLIERS OF RAW MATERIALS

APPENDIX – A:

01. PLANT ECONOMICS

02. LAND & BUILDING

03. PLANT AND MACHINERY

04. OTHER FIXED ASSESTS

05. FIXED CAPITAL

06. RAW MATERIAL

07. SALARY AND WAGES

08. UTILITIES AND OVERHEADS

09. TOTAL WORKING CAPITAL

10. TOTAL CAPITAL INVESTMENT

11. COST OF PRODUCTION

12. TURN OVER/ANNUM

13. BREAK EVEN POINT

14. RESOURCES FOR FINANCE

15. INSTALMENT PAYABLE IN 5 YEARS

16. DEPRECIATION CHART FOR 5 YEARS

17. PROFIT ANALYSIS FOR 5 YEARS

18. PROJECTED BALANCE SHEET FOR (5 YEARS)