Viscoelastic Solution

VISCOELASTIC SOLUTION

[EIRI/EDPR/4632]

Viscoelastics are also known as ophthalmic viscosurgical devices. They are solutions with dual properties. They have viscous properties of a fluid and elastic properties of a gel or a solid. They have also been described to have viscous, elastic, and pseudoplastic properties.

Viscoelastics are commonly used in cataract surgery to assist in capsulotomy and nucleus manipulation, corneal surgeries, glaucoma surgeries, open globe repairs, retinal surgery, pediatric and strabismus surgeries. Viscoelastics can be classified based on the source and rheological properties. The various complications associated with viscoelastics are secondary glaucoma, capsular block syndrome, capsular bag distension syndrome, pseudo anterior uveitis, IOL crystallization, and calcific band keratopathy.

COST ESTIMATION

Plant Capacity            3845 Kg/Day  

Land & Building (4000 sq.mt.)    Rs. 3.74 Cr    

Plant & Machinery                    Rs. 1.10 Cr 

Working Capital for 1 Month    Rs. 1.58 Cr 

Total Capital Investment          Rs. 6.53 Cr 

Rate of Return                          67%

Break Even Point                      35%

CONTENTS

INTRODUCTION

PROPERTIES & CHARACTERISTICS

PHYSICAL AND RHEOLOGICAL PROPERTIES OF VISCOELASTICS

VISCOSITY

PSEUDO-PLASTICITY

VISCOELASTICITY

RIGIDITY

SURFACE TENSION

VISCOADAPTABILITY

COHESIVENESS

DISPERSIVENESS

COATABILITY

CLASSIFICATION OF VISCOELASTICS

VISCOELASTICS ARE CLASSIFIED BASED ON THE

CLASSIFICATION BASED ON RHEOLOGICAL PROPERTIES

ARSHINOFF'S CLASSIFICATION

USES AND APPLICATION

CATARACT SURGERY

GLAUCOMA SURGERIES

CORNEAL SURGERIES

VISCOANAESTHESIA

VISCOMYDRIASIS

INTRAOPERATIVE FLOPPY IRIS SYNDROME (IFIS)

RETINAL SURGERY

ORBIT AND OCULOPLASTY SURGERY

PEDIATRIC OPHTHALMOLOGY AND STRABISMUS SURGERY

MANUFACTURING PROCESS OF VISCOELASTIC POLYMER (HPMC) HYDROXY PROPYL METHYL CELLULOSE

REACTION:

SIDE REACTION:

PROCESS FLOW DIAGRAM OF HPMC

PREPARATION OF VISCOELASTICS

SODIUM HYALURONATE

CHONDROITIN SULPHATE

VARIOUS PREPARATIONS OF CHONDROITIN SULPHATE

ISOLATED CHONDROITIN SULPHATE (20%)

CHONDROITIN SULPHATE AND SODIUM HYALURONATE

HYDROXYPROPYL METHYLCELLULOSE (HPMC)

SYNTHETIC VISCOELASTICS MATERIAL FOR OPHTHALMIC APPLICATION

EXAMPLE 1

VISCOELASTIC SOLUTIONS

SPECIALITIES

HYDROXY PROPYLMETHYL CELLULOSE OPHTHALMIC SOLUTION USP

AVAILABLE IN

CHARACTERISTICS

MARKET OVERVIEW OF VISCOLASTICS

GLOBAL OVERVIEW OF VISCOELASTIC

PRINCIPLES OF PLANT LAYOUT

STORAGE LAYOUT:

EQUIPMENT LAYOUT:

SAFETY:

PLANT EXPANSION:

FLOOR SPACE:

UTILITIES SERVICING:

BUILDING:

MATERIAL-HANDLING EQUIPMENT:

RAILROADS AND ROADS:

MAJOR PROVISIONS IN ROAD PLANNING FOR MULTIPURPOSE SERVICE ARE:

PLANT LOCATION FACTORS

PRIMARY FACTORS

1. RAW-MATERIAL SUPPLY:

2. MARKETS:

3. POWER AND FUEL SUPPLY:

4. WATER SUPPLY:

5. CLIMATE:

SPECIFIC FACTORS

6. TRANSPORTATION:

A. AVAILABILITY OF VARIOUS SERVICES AND PROJECTED RATES

7. WASTE DISPOSAL:

8. LABOR:

9. REGULATORY LAWS:

10. TAXES:

11. SITE CHARACTERISTICS:

12. COMMUNITY FACTORS:

13. VULNERABILITY TO WARTIME ATTACK:

14. FLOOD AND FIRE CONTROL:

EXPLANATION OF TERMS USED IN THE PROJECT REPORT

1. DEPRECIATION:

2. FIXED ASSETS:

3. WORKING CAPITAL:

4. BREAK-EVEN POINT:

5. OTHER FIXED EXPENSES:

6. MARGIN MONEY:

7. TOTAL LOAD:

8. LAND AREA/MAN POWER RATIO:

PROJECT IMPLEMENTATION SCHEDULES

INTRODUCTION

PROJECT HANDLING

PROJECT SCHEDULING

PROJECT CONSTRUCTION SCHEDULE

TIME SCHEDULE

ADDRESSES OF RAW MATERIAL SUPPLIERS

ADDRESSES OF PLANT & MACHINERY SUPPLIERS

APPENDIX – A:

01. PLANT ECONOMICS

02. LAND & BUILDING

03. PLANT AND MACHINERY

04. OTHER FIXED ASSESTS

05. FIXED CAPITAL

06. RAW MATERIAL

07. SALARY AND WAGES

08. UTILITIES AND OVERHEADS

09. TOTAL WORKING CAPITAL

10. TOTAL CAPITAL INVESTMENT

11. COST OF PRODUCTION

12. TURN OVER/ANNUM

13. BREAK EVEN POINT

14. RESOURCES FOR FINANCE

15. INSTALMENT PAYABLE IN 5 YEARS

16. DEPRECIATION CHART FOR 5 YEARS

17. PROFIT ANALYSIS FOR 5 YEARS

18. PROJECTED BALANCE SHEET FOR (5 YEARS)