Detailed Project Report on i.v. fluid manufacturing unit
Detailed Project Report on i.v. fluid manufacturing unit
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I.V. FLUID MANUFACTURING UNIT
[CODE NO.4074]
To start with, let us first understand the regulation of intravenous (IV) fluid. Intravenous fluid regulation has to do much with the control of the amount of fluid that is being received intravenously or via the bloodstream. This IV fluid is known to be administered via the intravenous line. The intravenous fluid is known to be administered for many different reasons. The rate of administration depends much on gravity alone.
The intravenous fluid flow is regulated manually or via the use of an electric pump. It is important to understand the regulation of the flow to ensure appropriate dosage as well as rate of flow and delivery. It is also important to understand the purpose of intravenous fluid regulation. Many reasons are to be known for fluids to be given at an intravenous level.
IV fluid is given for various reasons which are: (a) pain management, (b) cancer treatment via chemotherapy, (c) infection treatment via antibiotics, (d) rehydration after becoming much dehydrated. The IV fluids normally used for treatment consist of many medications, sugar, electrolytes, which are added in various different concentrations. When IV fluid is given to any individual, it is important to consider various factors such as age, medical condition, body size, and few more.
When IV fluid regulation is done, it ensures that appropriate amount of fluid drips are given through a bag at correct rate. When IV fluid regulation is too slow or too quick, many complications may arise thereafter. The intravenous fluid regulation can occur via manual way as well as via the use of an electric pump. For both these methods, it is important for the nurse to check the IV fluid intake at appropriate amounts.
When manual regulation is done, the nurse normally increases or decreases the pressure that is put on the intravenous tube through a clamp. The number of drops can be counted per minute to make any kind of adjustments that are otherwise required. The flow of IV fluid is also via the electric pump. Normally, the nurse programs the pump so that the right amount of fluid is administered in the patient’s body.
When a patient is given IV fluid, the doctor normally checks the amount as well as the rate t which it is administered. The skin over the injection site is normally disinfected by the nurse. Usually, the nurse locates the vein at the site and inserts a catheter. The catheter is normally inserted in and there should be no pain or just little pain. The administration of IV fluid is actually common and safe. At times, the flow is too slow or fast and it becomes important for the nurse to check the flow rate of the IV fluid. If there exist any symptoms such as trouble in breathing or headache, it is important to alert the patients right away. If the fluid intake is not in the right way, the patient might not just respond in the way that is expected out of him/her.
COST ESTIMATION
Plant Capacity 4,00,000 Nos/Day
Land & Building (6000 sq.mt.) Rs. 3.56 Cr
Plant & Machinery Rs. 82.63 Cr
Working Capital for 1 Month Rs. 11.02 Cr
Total Capital Investment Rs. 97.77 Cr
Rate of Return 34%
Break Even Point 50%
INTRODUCTION
STANDARD IVF & ELECTROLITES
THE AIMS OF IV FLUID ADMINISTRATION SHOULD BE TO
BASIC IV SETUP
LOCATION- ODISHA
MAP
DISTRICTS OF ORISSA
TRANSPORT NETWORK OF ORRISA
RAIL TRANSPORT
AIR
PORTS
PARADEEP PORT
GOPALPUR PORT
DHAMARA HARBOUR
TYPES OF IV FLUIDS
IV SOLUTIONS CAN ALSO BE CLASSIFIED BASED ON THEIR PURPOSE:
CRYSTALLOIDS
GENERAL CHARACTERISTICS OF CRYSTALLOID
ISOTONIC IV FLUIDS
0.9% NACL (NORMAL SALINE SOLUTION, NSS)
DEXTROSE 5% IN WATER (D5W)
LACTATED RINGER’S 5% DEXTROSE IN WATER (D5LRS)
RINGER’S SOLUTION
HYPOTONIC IV FLUIDS
0.33% SODIUM CHLORIDE (0.33% NACL)
0.225% SODIUM CHLORIDE (0.225% NACL)
2.5% DEXTROSE IN WATER (D2.5W)
HYPERTONIC IV FLUIDS
HYPERTONIC DEXTROSE SOLUTIONS
DEXTROSE 10% IN WATER (D10W)
DEXTROSE 20% IN WATER (D20W)
NURSING CONSIDERATIONS FOR HYPERTONIC SOLUTIONS
DARROW’S SOLUTION
COLLOIDS
HUMAN ALBUMIN
DEXTRANS
LOW-MOLECULAR-WEIGHT DEXTRANS (LMWD)
HIGH-MOLECULAR-WEIGHT DEXTRANS (HMWD)
IV FLUID/ELECTROLYTE THERAPY
NORMAL SALINE
VOLUME EFFECTS OF NS
RINGER'S FLUIDS
ADVANTAGE:
DEXTROSE SOLUTIONS
EFFECT OF DEXTROSE IN FLUID:
VOLUME EFFECTS
5%D
DNS
5 % DEXTROSE COMPOSITION:
DEXTROSE SALINE (DNS)
DEXTROSE WITH HALF STRENGTH SALINE
ISOLYTE G,M,P,E
METRONIDAZOLE IV SOLUTION
ECONOMIC PROFILE
MARKET SURVEY
APPLICATION INSIGHTS
VOLUME INSIGHTS
INDIA LARGE VOLUME PARENTERAL (LVP) MARKET SHARE INSIGHTS
NORTH AMERICA AT THE FOREFRONT OF THE GLOBAL INTRAVENOUS
(IV) SOLUTION MARKET
AFRICA’S PHARMACEUTICAL MARKET
BUSINESS JUSTIFICATION
PRODUCTS
WHY IV FLUID?
GLOBAL INTRAVENOUS SOLUTION MARKET: KEY TRENDS
GLOBAL INTRAVENOUS SOLUTION MARKET: SEGMENTATION
GLOBAL INTRAVENOUS SOLUTION MARKET: REGIONAL ANALYSIS
GLOBAL INTRAVENOUS SOLUTION MARKET: COMPETITIVE LANDSCAPE
MAJOR FIVE IV FLUID MONITORING DEVICES COMPANIES:
B. BRAUN MELSUNGEN AG
BAXTER INTERNATIONAL INC.
BECTON, DICKINSON AND CO.
FORTIVE CORP.
ICU MEDICAL INC.
SOURCE OF MACHINES TECHNOLOGY
USES AND APPLICATION
SOME GENERAL INTRAVENOUS FLUIDS
SPECIFICATION OF INDIAN PHARMACOPEIA ON I.V FLUIDS DEXTRAN
40 INJECTION
DEXTRAN 110 INJECTIONS
SODIUM CHLORIDE AND DEXTROSE INJECTION
ASSAY:
BASIC RAW MATERIALS
REQUIREMENTS OF RAW MATERIALS AND SPECIFICATIONS
WATER FOR INJECTION
HDPE PHARMA GRADE LAMINATE/ PLASTIC ROLL
LABELING
IDENTIFICATION
HEAVY METALS
COMPOSITION OF IV FLUID
COMPOSITION OF COMMON IV FLUID (MEQ/L)
COMPOSITION OF IV FLUIDS
COMPOSITION OF COMMERCIAL I.V. FLUID AVAILABLE
FORM FILL SEAL TECHNOLOGY
1. FORM-FILL-SEAL TECHNOLOGY:-
1.5 FILTRATION (MEMBRANE):-
1.6.3 THE STERILIZER SHALL BE DOUBLE ENDED TO PREVENT MIX-UPS.
1.7. STERILIZATION (BY DRY HEAT):-
LIST OF MACHINERY IV BAG PRODUCTION FORM FILL AND SEAL MACHINE
THE PRODUCTION OF I.V. SOLUTION PRODUCTION LINE CONSISTS OF
5 MAIN PHASES:
1. WATER PURIFYING
2. DISTILLATION
3. SOLUTION FILLING
4. STERILIZATION
5. PACKING
A TYPICAL FFS PROCESS WORKS AS FOLLOWS.
BASIC OF BFS TECHNOLOGY
BLOW FILL SEAL EQUIPMENT
BFS MOLDS AND TOOLING
BFS TRIALS
PROCESS
1. BLOW MOLDING
2. FILLING
3. SEALING
BLOW FILL SEAL MACHINES
ASEPTIC PACKAGING
BLOW FILL SEAL (BFS) AND FORM FILL SEAL (FFS) TECHNOLOGY
MANUFACTURING PROCESS OF I.V. FLUID
PROCESS IN DETAILS
1. DISTILLED WATER PREPARATION:-
2. SOLUTION PREPARATION:-
3. INJECTION BLOW MOULDING
4. MOULDING PROCESS
5. FILLING PROCESS
6. SEALING PROCESS
7. MOULD OPENING PROCESS
FILTRATION AND FILLING:-
STERILIZATION:-
QUALITY CONTROL:-
THE WHOLE PROCESS CONSISTS OF THE FOLLOWING STEPS:-
PROCESS FLOW DIAGRAM
FLOW DIAGRAM OF MANUFACTURING OF I.V. FLUIDS
SUPPLIERS OF RAW MATERIALS
POTASSIUM PERMANGANATE
SODIUM CHLORIDE (I.P. GRADE)
DEXTROSE
SUPPLIERS OF PLANT AND MACHINERY
STERILIZING EQUIPMENTS
PM METER
LABELING MACHINES
TANKS
BOILER
FILTER PRESS
LABORATORY EQUIPMENTS
MIXER
MACHINERY PHOTOGRAPHS
MULTIPLE EFFECT WATER DISTILLATION PLANT MIXER
STORAGE VESSEL
RAW MATERIAL SUPPLIER
SODIUM LACTATE
NACL
KCL CACL2
PRODUCT PHOTOGRAPHS
QUERY FROM CUSTOMERS
FISCAL INCENTIVES
FOR 10 MILLION BOTTLES PER MONTH WHAT KIND OF EQUIPMENT
WILL BE REQUIRED
LIST OF COMPANIES MANUFACTURING PLANT MACHINERIES AND
TOOLS REQUIRED
COST OF EACH EQUIPMENT
LIST OF RAW MATERIAL REQUIRED
LIST OF SUPPLIER OF RAW MATERIAL
COST OF RAW MATERIAL
BREAK DOWN MANUFACTURING COST
HOW MANY EMPLOYEES REQUIRED AND SALARY OF EACH EMPLOYEE?
SELLING PRICE
APPROVALS REQUIRED
LIST OF CONSULTANT THAT CAN HELP US IN GETTING THE APPROVAL
WHAT IS THE OPTIMUM PRODUCTION QUANTITY DEPENDING ON THE
DEMAND FOR A PLANT IN ODISHA
APPENDIX – A:
01. PLANT ECONOMICS
02. LAND & BUILDING
03. PLANT AND MACHINERY
04. OTHER FIXED ASSESTS
05. FIXED CAPITAL
06. RAW MATERIAL
07. SALARY AND WAGES
08. UTILITIES AND OVERHEADS
09. TOTAL WORKING CAPITAL
10. TOTAL CAPITAL INVESTMENT
11. COST OF PRODUCTION
12. TURN OVER/ANNUM
13. BREAK EVEN POINT
14. RESOURCES FOR FINANCE
15. INSTALMENT PAYABLE IN 5 YEARS
16. DEPRECIATION CHART FOR 5 YEARS
17. PROFIT ANALYSIS FOR 5 YEARS
18. PROJECTED BALANCE SHEET FOR (5 YEARS)
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