Detailed Project Report on dextrose saline (i.v. fluid) (ffs technology (Cap: 60,000 Bottles/day)

DEXTROSE SALINE (I.V. FLUID)(FFS TECHNOLOGY) (Cap: 60,000 Bottles/Day)
[CODE NO. 2085]  

Intra venous fluids, in general are used as I.V drips for patients in nursing homes and hospitals suffering from acute dehydration or considerable debilitating conditions.  These I.V fluids replanish the body fluids. Though a number of I.V fluids are there, generally three types of I.V fluids are used in hospitals as I.V drips. They are as follows:-

  1. Dextrose injection fluid

  2. Dextrose  and sodium chloride injection fluid

Types of IV Fluid

Crystalloid: Balanced salt/electrolyte solution; for msa true solution and is capable of passing through semi permeable membranes. May be isotonic, hypertonic or hypotonic. Normal Saline (0.9% NaCl), Lactated Ringer’s, Hypertonic saline (3, 5, & 7.5%), Ringer’s solution. However, hypertonic solutions are considered plasma expanders as they act to increase the circulatory volume via movement of intracellular and interstitial water into the intravascular space.

Colloid: High-molecular-weight solutions, draw fluid into intravascular compartment via on cotic pressure (pressure exerted by plasma proteins not capable of passing through membranes on capillary walls).Plasma expanders, as they are composed of macromolecules, and are retained in the intravascular space.

Free H2O solutions: provide water that is not bound by macromolecules or organelles, free to passthrough.D5W (5% dextrose in water), D10W, D20W, D50W, and Dextrose/crystalloid mixes. Blood products: whole blood, packed RBCs, FFP, Cryoprecipitate, platelets, albumin. Essentially all colloids.

IVF can supply 3 things: fluid, electrolytes, & calories. In the non stressed, fasting state, the 150g per day inD5W at 125ml/h can provide enough carbohydrate to limit proteolysis. The most common uses for IVF: Acutely expand intravascular volume in hypovolemic states correct electrolyte imbalances Maintain basal hydration


COST ESTIMATION

Plant Capacity                                               60000.00 BOTTLES/day
Land & Building (6000 Sq.Mtr)                   Rs. 3.69    Cr
Plant & Machinery                                         Rs. 12.00  Cr
W.C. for 2 Months                                          Rs. 2.6       Cr
Total Capital Investment                              Rs.  10.12  Cr
Rate of Return                                               22%
Break Even Point                                          61%

INTRODUCTION    
INTRAVENOUS FLUIDS    
IV FLUID/ELECTROLYTE THERAPY    
KEY TERMS    
DEXTROSE    
DEXTROSE SALINE INJECTION    
PROPERTIES    
REQUIREMENTS OF RAW MATERIALS    
EXPORT OPPORTUNITY OF INTRAVENOUS SOLUTION    
INTERNATIONAL MARKET OVERVIEW    
ECONOMIC PROFILE    
WORLD MARKET CONSUMPTION    
SOURCE OF MACHINES TECHNOLOGY    
OVERVIEW OF THE GLOBAL INTRAVENOUS SOLUTIONS MARKET    
IV FLUID PRODUCTION CAPACITY AND MARKET DEMAND IN AFGHANISTAN    
USES AND APPLICATION    
SOME GENERAL INTRAVENOUS FLUIDS    
MARKET SURVEY    
MARKET STRACTURE    
INDIAN BULK DRUG MARKET SHARE    
ADDITIONAL MARKET POSITION    
INDIAN PATENTS LAW, TRADE LAW & TAXATION    
'TAX'ING INDIAN PHARMA    
PRESENT MANUFACTURES OF I.V FLUIDS    
SPECIFICATION OF INDIAN PHARMACOPEIA ON I.V FLUIDS DEXTRAN 40 INJECTION    
DEXTRAN 110 INJECTIONS    
B.I.S. SPECIFICATIONS FOR PLASTIC I.V. BOTTLES    
SODIUM CHLORIDE AND DEXTROSE INJECTION    
WATER THE EXCELLENT SOLVENT USED IN PHARMACY
BASIC RAW MATERIALS    
REQUIREMENTS OF RAW MATERIALS AND SPECIFICATIONS    
COMPOSITION OF IV FLUID    
COMPOSITION OF COMMON IV FLUID (MEQ/L)    
COMPOSITION OF IV FLUIDS    
COMPOSITION OF COMMERCIAL I.V. FLUID AVAILABLE    
MANUFACTURING PROCESS OF I.V. FLUID (FFS TECHNOLOGY)    
PROCESS FLOW DIAGRAM    
PROCESS IN DETAILS    
FLOW DIAGRAM OF MANUFACTURING OF I.V. FLUIDS    
PLANT LAYOUT    
SWOT ANALYSIS    
SCHEMATIC DIAGRAM OF FFS PLANT LAYOUT    
FORM FILL SEAL TECHNOLOGY    
CALCULATING INTRAVENOUS FLOW RATES    
GENERAL PLANT LAYOUT    
MANPOWER    
LIST OF MACHINERY IV BAG PRODUCTION FORM FILL AND SEAL MACHINE    
CIP SYSTEM    
GUIDE TO GOOD MANUFACTURING PRACTICE (GMP) FOR MEDICINAL PRODUCT PRINCIPLE    
CLEAN ROOM AND CLEAN AIR DEVICE CLASSIFICATION    
CLEAN ROOM AND CLEAN AIR DEVICE MONITORING    
ISOLATOR TECHNOLOGY    
TERMINALLY STERILISED PRODUCTS    
ASEPTIC PREPARATION    
PERSONNEL    
PREMISES    
EQUIPMENT    
SANITATION    
PROCESSING    
STERILISATION    
STERILISATION BY HEAT    
MOIST HEAT    
STERILISATION BY RADIATION    
STERILISATION WITH ETHYLENE OXIDE    
FILTRATION OF MEDICINAL PRODUCTS WHICH CANNOT
   BE STERILISED IN THEIR FINAL CONTAINER    
FINISHING OF STERILE PRODUCTS    
SUPPLIERS OF RAW MATERIALS    
EMPTY IV BAG MANUFACTURER AND SUPPLIER IN INDIA    
COMPLETE PLANT SUPPLIERS    
SUPPLIERS OF PLANT AND MACHINEY    
CONSULTANT OF TURNKEY PROJECT SUPPLIER
  OF THE PLANT AND MACHINERY    
CLEAN ROOM SUPPLIERS    


APPENDIX – A :

 1.      COST OF PLANT ECONOMICS      
 2.      LAND & BUILDING                                      
 3.      PLANT AND MACHINERY                                  
 4.      FIXED CAPITAL INVESTMENT                             
 5.      RAW MATERIAL                                         
 6.      SALARY AND WAGES                                     
 7.      UTILITIES AND OVERHEADS                              
 8.      TOTAL WORKING CAPITAL                                
 9.      COST OF PRODUCTION                                   
10.      PROFITABILITY ANALYSIS                               
11.      BREAK EVEN POINT                                     
12.      RESOURCES OF FINANCE                           
13.      INTEREST CHART                                       
14.      DEPRECIATION CHART                                   
15.      CASH FLOW STATEMENT                                   
16.      PROJECTED BALANCE SHEET