Detailed Project Report on Micro Crystalline Cellulose (Pharma, Food & Non Pharma Grade)

MICRO CRYSTALLINE CELLULOSE (PHARMA, FOOD & NON PHARMA GRADE)

[EIRI/EDPR/3366] J.C.: 1450 

INTRODUCTION

Microcrystalline cellulose, also known as MCC or cellulose gel, is commonly used as a binder and disintegrant in pharmaceutical tablets, as a suspending agent in liquid pharmaceutical formulations, and as a binder and stabilizer in food applications including beverages and as stabilizers, binders, disintegrants and processing aids in industrial applications, household products such as detergent and/or bleach tablets, agricultural formulations, and personal care products such as dentifrices and cosmetics. In foods, MCC is used alone or in coprocessed modifications as a fat replacer. The classic process for MCC production is acid hydrolysis of purified cellulose. In efforts to reduce the cost while maintaining or improving the quality of MCC, various alternative processes have been proposed. Among these are steam explosion, reactive extrusion, one-step hydrolysis and bleaching, and partial hydrolysis of a semi-crystalline cellulose and water reaction liquor in a reactor pressurized with oxygen and/or carbon dioxide gas and operating at 100 to 200°C. In the steam explosion process of Ha et al, a cellulose source material, such as wood chips, is contacted in a pressure reactor vessel with pressurized steam at a temperature of at least about 170°C for a brief period, concluding with a rapid release of the steam pressure (the "steam explosion" effect). 

COST ESTIMATION

Plant Capacity            5 MT/Day

Land & Building (2000 sq.mt.)    Rs. 2.97 Cr

Plant & Machinery                    Rs. 4.00 Cr

Working Capital for 2 Months    Rs. 2.03 Cr

Total Capital Investment          Rs. 9.42 Cr

Rate of Return                          32%

Break Even Point                      50%

CONTENTS
INTRODUCTION    
MICRO CRYSTALLINE CELLULOSE    
MICRO CRYSTALLINE CELLULOSE    
APPLICATIONS    
SPECIFICATION    
USES AND APPLICATION    
CELLULOSE IS USED IN THE FOLLOWING PRODUCTS:    
FIBERS:-    
FILMS:-
CELLOPHANE:-    
SAUSAGE CASINGS:-    
ARTIFICIAL KIDNEYS:-    
REVERSE OSMOSIS:-    
GUMS & THICKNESS    
FOODS & PHARMACEUTICALS FOODS    
PHARMACEUTICALS    
COSMETICS    
MARKET SURVEY    
EXPORT DATA OF MICRO CRYSTALLINE CELLULOSE    
IMPORT DATA OF MICRO CRYSTALLINE CELLULOSE    
PRESENT MANUFACTURERS/SUPPLIERS OF MICRO CRYSTALLINE CELLULOSE    
B I S SPECIFICATION    
1.  SCOPE    
2.  REQUIREMENTS    
3.  PACKING AND MARKING    
4.  SAMPLING    
5.  TEST METHODS    
METHODS OF TEST    28
SAMPLING OF CELLULOSE POWDER    
CELLULOSE DERIVATES    
1.  CELLULOSE ACETATE:    
2.  SIMPLE TRIESTERS:    
3.  CELLULOSE ESTERS OF AROMATIC ACIDS:    
4.  BENZOATE ESTERS:    
5.  CELLULOSE ESTERS OF UNSATURATED CARBOXYLIC ACIDS:    
6.  MIXED ESTERS:    
SPECIFICATION OF MICROCRYSTALLINE CELLULOSE    
COMPARISON CHART OF SPECIFICATOINS    
MICROCRYSTALLINE CELLULOSE, IP (SPRAY DRIED)    
MICROCRYSTALLINE CELLULOSE, IP (BULK DRIED)    
SPECIFICATION OF FOOD GRADE (MCC)    
RAW MATERIALS    
PROPERTIES    
PHYSICAL PROPERTIES:    
HEAT EFFECTS :    
SOLUBILITY :    
CHEMICAL PROPERTIES :    
PROPERTIES IN ALKALINE SOLUTION:    
EFFECT OF MINERAL ACIDS :    
EFFECT OF OXIDIZING AGENTS :    
ALCOHOLIC PROPERTIES :    
ETHER FORMATION :    
MANUFACTURING PROCESS OF MICROCRYSTALLINE CELLULOSE POWDER    
PROCESS FLOW DIAGRAM    
PROCESS DETAILS    
1.  WOOD PREPARATION :    
2.  PULPING:
MECHANICAL PULPING :    
CHEMICAL PULPING :    
SULFITE PROCESSES :    
ALKALINE PROCESSES :    
PURIFICATION ;    
OXIDATIVE BLEACHING : CHLORINE.    
OTHER AGENTS :    
REDUCTIVE BLEACHING:    
OTHER REACTIONS :    
THE USUAL METHODS INCLUDE EITHER OR BOTH OF THESE STEPS:    
PRODUCTION OF MICROCRYSTALLINE CELLULOSE USING REACTIVE
EXTRUSION PROCESS    
TEST METHODS    
TABLE 1: TABLET PROPERTIES    
MANUFACTURING PROCESS OF MICRO CRYSTALLINE CELLULOSE FROM CORN HUSK    
MATERIALS AND METHOD    
MATERIALS    
METHOD    
PREPARATION OF MAIZE HUSK POWDER:    
EXTRACTION OF CELLULOSE FROM CORN HUSK:
MICRO CRYSTALLINE CELLULOSE FROM COTTON RAGS    
REAGENTS AND CHEMICALS    
MCC PREPARATION    
PURITY AND IDENTIFICATION TEST    
SUPPLIERS OF RAW MATERIALS    
SUPPLIERS OF PLANT AND MACHINERY    

APPENDIX – A:

01. PLANT ECONOMICS

02. LAND & BUILDING

03. PLANT AND MACHINERY

04. OTHER FIXED ASSESTS

05. FIXED CAPITAL

06. RAW MATERIAL

07. SALARY AND WAGES

08. UTILITIES AND OVERHEADS

09. TOTAL WORKING CAPITAL

10. TOTAL CAPITAL INVESTMENT

11. COST OF PRODUCTION

12. TURN OVER/ANNUM

13. BREAK EVEN POINT

14. RESOURCES FOR FINANCE

15. INSTALMENT PAYABLE IN 5 YEARS

16. DEPRECIATION CHART FOR 5 YEARS

17. PROFIT ANALYSIS FOR 5 YEARS

18. PROJECTED BALANCE SHEET FOR (5 YEARS)