Detailed Project Report on solvent extraction method for curcumin

SOLVENT EXTRACTION METHOD FOR CURCUMIN
 [CODE NO. 2081]  

Curcumin (synonyms: turmeric yellow, kurkum, INS No. 100(i)) is an orange-yellow crystalline powder. Minor amounts of oils and resins naturally occurring in turmeric may be present.

The origin of the plant Curcuma longa L., which belongs to Zingiberaceae family is India. The plant is distributed throughout tropical and subtropical regions of the world, being widely cultivated in southeast Asian countries. Turmeric, i.e., the ground rhizomes of Curcuma longa L., has a long history of use in food as a spice, mainly as an ingredient in many varieties of curry powders and sauces, where curcumin from turmeric is a main colouring substance.

The turmeric (Curcuma longa) plant, a perennial herb belonging to the ginger family, is cultivated extensively in south and southeast tropical Asia. The rhizome of this plant is also referred to as the ―root and is the most useful part of the plant for culinary and medicinal purposes. The most active component of turmeric is curcumin, which makes up 2 to 5% of the spice. The characteristic yellow color of turmeric is due to the curcuminoids, first isolated by Vogel in 1842. Curcumin is an orange–yellow crystalline powder practically insoluble in water. The structure of curcumin (C 21 H 20 O 6) was first described in 1910 by Lampe and Milobedeska and shown to be diferuloylmethane. Turmeric is used as a dietary spice, coloring agent in foods and textiles, and a treatment for a wide variety of ailments. It is widely used in traditional Indian medicine to cure biliary disorders, anorexia, cough, diabetic wounds, hepatic disorders, rheumatism, and sinusitis. Turmeric paste in slaked lime is a popular home remedy for the treatment of inflammation and wounds. For centuries, curcumin has been consumed as a dietary spice at doses up to 100 mg/d. Extensive investigation over the last five decades has indicated that curcumin reduces blood cholesterol. (Aggarwal et al., 2006).

Turmeric was described as C. longa by Linnaeus and its taxonomic position is as follows:

Class     Liliopsida
Subclass     Commelinids
Order     Zingiberales
Family     Zingiberaceae
Genus     Curcuma
Species     Curcuma longa

The wild turmeric is called C. aromatica and the domestic species is called C. longa. For the last few decades, extensive work has been done to establish the biological activities and pharmacological actions of turmeric and its extracts. Curcumin (diferuloylmethane), the main yellow bioactive component of turmeric has been shown to have a wide spectrum of biological actions. These include its anti-inflammatory, antioxidant, anticarcinogenic, antimutagenic, anticoagulant, antifertility, antidiabetic, antibacterial, antifungal, antiprotozoal, antiviral, antifibrotic, antivenom, antiulcer, hypotensive and hypocholesteremic activities. Its anticancer effect is mainly mediated through induction of apoptosis. It’s anti-inflammatory, anticancer and antioxidant roles may be clinically exploited to control rheumatism, carcinogenesis and oxidative stress-related pathogenesis. Clinically, curcumin has already been used to reduce post-operative inflammation. Safety evaluation studies indicate that both turmeric and curcumin are well tolerated at a very high dose without any toxic effects. Thus, both turmeric and curcumin have the potential for the development of modern medicine for the treatment of various diseases.

Turmeric (Curcuma longa) is a native of Asia & India. The tuberous  rhizone or underground steam of turmeric are used from antiquity as condiments. A dye and as an aromatic stimulants in several medicines. Turmeric is a very important spice in India, which produces nearly the whole world crop & uses 80% of it presently. It is cultivated in china, Taiwan, Indonesia, Sri Lanka, Australia, Africa, Peru & the West Indies. Turmeric uses dates back nearly 4000 years, to the vodic culture in India, when turmeric was the principal spice & also of religious significance. It is much reversed by thindus & associated with fertility. In to days India's, turmeric still added to nearly every dish be it meat or vegetables. Turmeric has been used in Indian systems of medicine for a long time.

The turmeric has been used in herbal dating from about 600 BC and it also mentioned by Dioscorides. In malaysia the paste of turmeric is spread on the mothers abdomen and on the umbilical cord after child Birth. Not only to warm off one spirits, but also for its medicinal value. Bath the East & West have held its medicinal properties in high regards. Rhizomes are the used plant port. Fresh turmeric leaves are used in some regions of Indonesia as flavouring. The rootstick has aromatic & Spicy pogoonce, which by drying gives way to a more medicinal Aroma. On storing, the smell rather quickly change to earthy and unpleasant.   Similarly the colour of ground turmeric tends to fade if the spice is trolong. It is called Indian saffron because of its orange yellow colour. In language the name of turmeric just mean yellow root, English turmeric derived from the (Now absolute) french terremerite, probably because ground turmeric resembles mineral pigments (ochor),. The genus name Curcuma is of the same origin, being a latinization of Arabic Kurkum meaning saffron.

Distribution Turmeric (curcuma longa) is a native of Asia & India. The wild curcuma species, from which alonga evalved, is presumed to have attracted attention as on incidental source of food or because of its yellowish colour it night have acquired magical properties. Turmeric usage vedic culture in India. It is the most significance spice in India. In biblical times, it was used as a perfume as well as spice. In India it is used as medicine for a long time. It is listed in an Assyian herbal dating from about 600 BC. Turmeric is distributed in India specially in celebes. The Moluccas & Polynesia. This suggests an early cultural connection between the people of these areas of the indigenous per Aryan cultivates of India. It reaches China before the 7th century A. Du East Africa in 8th century A.D. & West Africa in the 13th century.

What is Turmeric?

Turmeric is a member of the Curcuma botanical group, which is part of the ginger family of herbs, the Zingiberaceae. The root and rhizome (underground stem) of the Curcuma longa L. plant is crushed and powdered into ground Turmeric. Ground Turmeric is used worldwide as a seasoning, the main ingredient in curry and as a source for Curcumin (Turmeric contains approximately 5% Curcumin) and its therapeutic effects.


COST ESTIMATION

Plant Capacity                                               30.00 Kgs/day
Land & Building (1000 Sq.Mtr)                   Rs. 1.36    Cr
Plant & Machinery                                         Rs. 1.20   Cr
W.C. for 2 Months                                          Rs. 66.89  Lacs
Total Capital Investment                              Rs. 3.30  Cr
Rate of Return                                                25%
Break Even Point                                           56%

INTRODUCTION    
PRODUCT SPECIFICATION    
USES AND APPLICATION    
PROPERTIES OF CURCUMIN    
CHEMICAL CHARACTERIZATION OF CURCUMIN    
CURCUMIN - THE YELLOW EXTRACT FROM TURMERIC    
CHEMICAL COMPOSITION OF TURMERIC    
PHARMACOLOGICAL ACTION OF TURMERIC AND IT’S EXTRACT    
FRAGRANCE AND FLAVOUR    
RAW MATERIALS SCENARIO (INDIA AND GLOBAL)    
OVERVIEW OF CURCUMIN MARKET    
MARKET SURVEY    
PRODUCTION OF CURCUMIN IN INDIA    
CURCUMIN MARKET FORE CAST    
PRESENT MANUFACTURERS OF CURCUMIN    
PROCESS OUTLINE FOR CURCUMIN EXTRACTION    
MANUFACTURING PROCESS OF CURCUMIN    
BASIC PLANT AND MACHINERY REQUIRED.    
SALIENT FEATURE OF THE PROCESS    
MANUFACTURING PROCESS DIAGRAM    
TECHNICAL DETAILS FOR CURCUMIN EXTRACTION    
EXTRACTION AND PROCESSING OF CURCUMIN    
QUADRA PERCOLATION SYSTEM      
SWOT ANALYSIS OF CURCUMIN    
SUPPLIERS OF RAW MATERIAL (INDIAN)    
SUPPLIERS OF RAW MATERIAL (GLOBAL)    
SUPPLIERS OF PLANT AND MACHINRY    


APPENDIX – A :

 1.      COST OF PLANT ECONOMICS      
 2.      LAND & BUILDING                                      
 3.      PLANT AND MACHINERY                                  
 4.      FIXED CAPITAL INVESTMENT                             
 5.      RAW MATERIAL                                         
 6.      SALARY AND WAGES                                     
 7.      UTILITIES AND OVERHEADS                              
 8.      TOTAL WORKING CAPITAL                                
 9.      COST OF PRODUCTION                                   
10.      PROFITABILITY ANALYSIS                               
11.      BREAK EVEN POINT                                     
12.      RESOURCES OF FINANCE                           
13.      INTEREST CHART                                       
14.      DEPRECIATION CHART                                   
15.      CASH FLOW STATEMENT                                   
16.      PROJECTED BALANCE SHEET